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Effect of microencapsulation of egg yolk immunoglobulin Y by sodium alginate/chitosan/sodium alginate on the growth performance, serum parameters, and intestinal health of broiler chickens |
Yuanming Jin1,2,a 
, Haojie Lv1,a
, Mingzhu Wang1,2
, Chong-Su Cho3
, Jongsuh Shin4
, Lianhua Cui1,2,*
, Changguo Yan1,2,5,*
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1Department of Animal Science, Yanbian University, Yanji, Jilin 133002, China
2Engineering Research Center of North-East Cold Region Beef Cattle Science and Technology Innovation, Ministry of Education,Yanbian University, Yanji, Jilin 133002, China
3Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
4Department of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Korea
5Yanbian Hongchao Smart Animal Husbandry Co., Ltd, Yanji, Jilin 133002, China |
Correspondence:
Lianhua Cui, Tel: +86-433-2435518, Email: cuilianhua@ybu.edu.cn
Changguo Yan, Tel: +86-433-2435631, Email: ycg@ybu.edu.cn
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Received: 31 October 2022 • Revised: 11 January 2023 • Accepted: 10 February 2023
aThese authors contributed equally to this work. |
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| Abstract |
Objective
Egg yolk immunoglobulin (IgY) is an antibiotic alternative to prevent and fight intestinal pathogenic infections. This study aimed to investigate the effects of sodium alginate/chitosan/sodium alginate IgY microcapsules on the growth performance, serum parameters, and intestinal health of broiler chickens.
Methods
One-day-old broilers (Ross 308) were divided into five treatments, each with 10 replicates of five chickens. The dietary treatments were maintained for 28 days and consisted of a basal diet (NC), basal diet + 500 mg chlortetracycline/kg diet (CH), basal diet + 50 mg non-microencapsulated IgY/kg diet (NM), basal diet + 600 mg low levels microencapsulated IgY/kg diet (LM), and basal diet + 700 mg high levels microencapsulated IgY/kg diet (HM).
Results
Throughout the 28-day trial period, the NM, LM, HM, and CH groups increased average daily gain compared with the NC group (p<0.05), and the HM group reduced feed conversion ratio compared with the CH group (p<0.05). The LM and HM groups increased relative organ weights of thymus and spleen compared with the CH and NM groups (p<0.05). The HM group improved the duodenal, jejunal and ileum villi height (VH) and villus height to crypt depth ratio (VH:CD) compared with the CH and NM groups (p<0.05). Compared with the CH group, the HM group increased serum immunoglobulin (IgA), immunoglobulin G (IgG), superoxide dismutase, total antioxidant capacity, and glutathione peroxidase levels (p<0.05), and decreased serum malondialdehyde levels (p<0.05). Compared with the NC group, the NM, LM, HM, and CH groups reduced colonic Escherichia coli and Salmonella levels (p<0.05). and the HM group promoted the levels of lactic acid bacteria and bifidobacteria compared with the CH group (p<0.05).
Conclusion
Microencapsulation could be considered as a way to improve the efficiency of IgY. The 700 mg high levels microencapsulated IgY/kg diet could potentially be used as an alternative to antibiotics to improve the immune performance and intestinal health, leading to better performance of broiler chickens. |
| Keywords:
Broiler; Immunoglobulin Y (IgY); Immune Performance; Intestinal Flora; Intestinal Morphology; Microencapsulation; Production Performance |
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